GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7581224 | 1 | rs7581224 | chr2:84709215 | DNAH6 | chr2:84743579-85046711:+ | 0.42 | 7.71 | 1.11E-13 | Coronary artery calcification |
| BLCA | cis | rs2239557 | 1 | rs75824542 | chr14:74523047 | LIN52 | chr14:74551656-74667117:+ | 0.34 | 7.84 | 4.54E-14 | Common traits (Other) |
| BLCA | cis | rs9309473 | 1 | rs7582606 | chr2:73813945 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.21 | 3.04E-7 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs7583255 | chr2:73797996 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.1 | 5.44E-7 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs7584575 | chr2:73666402 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.93 | 6.88E-9 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs7585004 | chr2:73666645 | ALMS1P | chr2:73872046-73912692:+ | 0.41 | 6.13 | 2.25E-9 | Metabolite levels |
| BLCA | cis | rs882367 | 1 | rs758598 | chr17:59492714 | C17orf82 | chr17:59489112-59490641:+ | 0.2 | 4.46 | 1.1E-5 | Sitting height ratio |
| BLCA | cis | rs882367 | 1 | rs758599 | chr17:59492268 | C17orf82 | chr17:59489112-59490641:+ | 0.21 | 4.61 | 5.57E-6 | Sitting height ratio |
| BLCA | cis | rs9309473 | 1 | rs7586463 | chr2:73798476 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 5.08 | 5.97E-7 | Metabolite levels |
| BLCA | cis | rs2143950 | 1 | rs75889859 | chr14:35539054 | PPP2R3C | chr14:35554679-35591679:- | 0.25 | 3.98 | 8.27E-5 | Atopic dermatitis |
| BLCA | cis | rs7789940 | 1 | rs758944 | chr7:75953297 | UPK3B | chr7:76139745-76157197:+ | -0.31 | -6.43 | 3.81E-10 | Multiple sclerosis |
| BLCA | cis | rs7589728 | 1 | rs7589728 | chr2:88518440 | THNSL2 | chr2:88469835-88486145:+ | -0.57 | -5.54 | 5.49E-8 | Plasma clusterin levels |
| BLCA | cis | rs12220777 | 1 | rs75913297 | chr10:81789845 | LOC219347 | chr10:81805991-81838949:- | 0.35 | 4.34 | 1.81E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs7591472 | 1 | rs7591472 | chr2:201889751 | CFLAR | chr2:201980816-202029001:+ | -0.24 | -4.42 | 1.27E-5 | Triptolide cytotoxicity |
| BLCA | cis | rs7591472 | 1 | rs7591472 | chr2:201889751 | PPIL3 | chr2:201735680-201753999:- | -0.64 | -9.21 | 2.23E-18 | Triptolide cytotoxicity |